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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Updated: Dec 11, 2025

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The costs outweigh the benefits: seeing side-effects online may decrease adherence to statins.

Nickolas M Jones1, Dana B Mukamel2, Shaista Malik3

  • 1Department of Psychological Science, University of California, Irvine, Irvine, CA, USA. nmjones@uci.edu.

BMC Medical Informatics and Decision Making
|August 22, 2020
PubMed
Summary

Information about statin benefits and side effect management online increases adherence recommendations. Exposure to medical misinformation or side effects alone did not impact decisions, highlighting the nuanced effect of health information.

Keywords:
Health decision-makingHealth-information seekingMedical websitesStatins

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Area of Science:

  • Health communication
  • Medical informatics
  • Patient adherence

Background:

  • Growing concern over online medical misinformation potentially reducing patient adherence to prescriptions.
  • Limited understanding of how specific online information encountered during searches influences decisions regarding physician recommendations.
  • Statin prescriptions were utilized as a case study to investigate these issues.

Purpose of the Study:

  • To assess the impact of online health information quality on patient decisions regarding statin adherence.
  • To analyze how exposure to different types of information (benefits, side effects, misinformation) affects recommendations for medication adherence.
  • To develop a tool for ranking the quality of health-related web pages.

Main Methods:

  • Developed a tool to evaluate statin-related web page quality based on specific content criteria.
  • Conducted an experiment where participants searched for statin information for a hypothetical relative.
  • Logged participant search activity and analyzed website quality scores to predict recommendations.

Main Results:

  • Exposure to information on statin benefits and side effect management was linked to a higher likelihood of recommending adherence.
  • Encountering medical misinformation or details about side effects did not significantly influence adherence recommendations.
  • Qualitative analysis revealed side effects were a prominent concern for those not recommending adherence.

Conclusions:

  • Online health information is not uniformly perceived; specific content elements significantly influence health decisions.
  • The study provides granular insights into how internet searches impact decisions about evidence-based medications.
  • Physicians should proactively discuss online health information with patients to address potential non-adherence.