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Updated: Dec 11, 2025
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
High initial bowel resection rate and very-early-onset inflammatory bowel disease - A challenge in a low-prevalence
Pai-Jui Yeh1, Chien-Chang Chen1, Hsun-Chin Chao1
1Division of Pediatric Gastroenterology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou Branch and Chang Gung University College of Medicine, Taoyuan, Taiwan.
Insights
Pediatric inflammatory bowel disease (IBD) incidence is rising globally, including Taiwan. Early diagnosis and treatment are crucial for managing Crohn
Area of Science:
- Pediatric Gastroenterology
- Inflammatory Bowel Disease Research
- Genetics of Autoimmune Disorders
Background:
- Inflammatory bowel diseases (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), have seen a global rise in pediatric incidence.
- This trend is also evident in Taiwan, necessitating localized studies on pediatric IBD (pIBD).
Purpose of the Study:
- To characterize the clinical features and outcomes of pediatric IBD patients treated at a tertiary center over two decades.
- To analyze trends in pIBD incidence and identify associated risk factors.
Main Methods:
- Retrospective chart review of pIBD patients diagnosed between 2000 and 2018.
- Analysis of demographics, clinical presentations, diagnostic methods, treatments, and patient outcomes.
Main Results:
- A nearly threefold increase in pIBD incidence was observed after 2010.
- Early-onset disease and genetic mutations (XIAP, TTC7A, ZAP70) were noted in some patients.
- Forty percent of Crohn's disease patients required initial bowel resection, linked to disease behavior and growth failure.
Conclusions:
- Taiwan, a previously low-prevalence region, is experiencing an increasing incidence of pediatric IBD.
- High rates of initial bowel resection in pediatric Crohn's disease are associated with aggressive disease phenotypes and early diagnosis.
Background:
Inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn's disease (CD). The incidence in children and adolescents has risen since the 21st century globally, including Taiwan. The study aimed to disclose the characteristics and outcome of pediatric IBD (pIBD) patients in a tertiary center for the past two decades.
Methods:
We retrospectively reviewed the charts of pIBD children from 2000 to 2018 in a tertiary center in Northern Taiwan. Demographics, presentations, diagnostic modalities, treatment, and outcomes were analyzed.
Results:
A total of 38 cases were enrolled, including 27 CD and 11 UC patients. An almost 3-folds increase in incidence after 2010 was observed. Twelve cases (32%) were early-onset, and six of them (16%) were very-early-onset; four of them were detected with single-gene mutations [XIAP, TTC7A (2 siblings), and ZAP70]. Eleven CD patients (40.7%) received bowel resection at the onset, and another two (7.4%) had bowel resection years after the diagnosis. Initial bowel resection was associated with fibrostenotic/penetrating behavior, early-onset disease, and growth failure.
Conclusion:
This study demonstrated an increased incidence of pIBD in the past two decades in Taiwan, a low-prevalence region. The initial high bowel resection rate in CD was related to the fibrostenotic and/or penetrating behavior, younger age at diagnosis, and growth failure.
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