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SGLT2 and cancer
1Physiology Department, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095-1751, USA. Ewright@mednet.ucla.edu.
Pflugers Archiv : European Journal of Physiology
|August 22, 2020
Summary
New imaging tracer Me4FDG reveals sodium-dependent glucose cotransporter (SGLT) activity in tumors. This SGLT2 imaging may offer a more complete picture of tumor metabolism and potential new therapeutic avenues.
Area of Science:
- Oncology
- Radiochemistry
- Molecular Imaging
Background:
- Glycolysis is crucial for tumor metabolism, leading to high glucose uptake.
- Facilitated glucose transporter 1 (GLUT1) upregulation is often assumed to meet this demand.
- Standard 2-deoxy-2-fluoro-18F-fluorodeoxyglucose (2FDG) PET imaging targets GLUT1 but not sodium-dependent glucose cotransporters (SGLTs).
Purpose of the Study:
- To introduce Me4FDG, a novel radiotracer for imaging SGLT activity.
- To explore the role of SGLTs in supporting tumor glycolysis.
- To evaluate Me4FDG PET for visualizing SGLT expression in cancer patients.
Main Methods:
- Development of the Me4FDG radiotracer.
- Preliminary studies using Me4FDG PET in cancer patients.
- Analysis of SGLT isoform expression in tumor tissues.
Main Results:
- Me4FDG enables imaging of SGLT activity.
- The renal isoform, SGLT2, is expressed in pancreatic cancer, prostate cancer, and glioblastomas.
- Me4FDG PET provides a novel imaging approach for these tumors.
Conclusions:
- Me4FDG PET offers a new method to visualize SGLT activity in specific tumors.
- SGLT2 expression in tumors suggests potential therapeutic strategies targeting SGLT2.
- SGLT2 inhibitors, successful in diabetes treatment, may offer new cancer therapies.
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