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Related Concept Videos

Secondary Active Transport01:32

Secondary Active Transport

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One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
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Secondary Active Transport01:55

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One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
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Glucose Transporters01:27

Glucose Transporters

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Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
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Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Updated: Dec 11, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

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SGLT2 and cancer.

Ernest M Wright1

  • 1Physiology Department, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095-1751, USA. Ewright@mednet.ucla.edu.

Pflugers Archiv : European Journal of Physiology
|August 22, 2020
PubMed
Summary
This summary is machine-generated.

New imaging tracer Me4FDG reveals sodium-dependent glucose cotransporter (SGLT) activity in tumors. This SGLT2 imaging may offer a more complete picture of tumor metabolism and potential new therapeutic avenues.

Keywords:
GlioblastomaInhibitorsPETSGLT2

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Area of Science:

  • Oncology
  • Radiochemistry
  • Molecular Imaging

Background:

  • Glycolysis is crucial for tumor metabolism, leading to high glucose uptake.
  • Facilitated glucose transporter 1 (GLUT1) upregulation is often assumed to meet this demand.
  • Standard 2-deoxy-2-fluoro-18F-fluorodeoxyglucose (2FDG) PET imaging targets GLUT1 but not sodium-dependent glucose cotransporters (SGLTs).

Purpose of the Study:

  • To introduce Me4FDG, a novel radiotracer for imaging SGLT activity.
  • To explore the role of SGLTs in supporting tumor glycolysis.
  • To evaluate Me4FDG PET for visualizing SGLT expression in cancer patients.

Main Methods:

  • Development of the Me4FDG radiotracer.
  • Preliminary studies using Me4FDG PET in cancer patients.
  • Analysis of SGLT isoform expression in tumor tissues.

Main Results:

  • Me4FDG enables imaging of SGLT activity.
  • The renal isoform, SGLT2, is expressed in pancreatic cancer, prostate cancer, and glioblastomas.
  • Me4FDG PET provides a novel imaging approach for these tumors.

Conclusions:

  • Me4FDG PET offers a new method to visualize SGLT activity in specific tumors.
  • SGLT2 expression in tumors suggests potential therapeutic strategies targeting SGLT2.
  • SGLT2 inhibitors, successful in diabetes treatment, may offer new cancer therapies.