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Tooth loss associated with the use of tenofovir disoproxil fumarate
Long Jianfei1, Li Ling1,2, Zhang Yu1
1Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China.
What Is Known And Objective:
The frequent tenofovir disoproxil fumarate (TDF)-related adverse drug reactions (ADRs) are nephrotoxicity and bone toxicity; however, tooth-related ADRs of TDF have not been reported. We describe the case of a 41-year-old Han Chinese man with chronic hepatitis B with TDF-associated tooth loss.
Case Summary:
He presented with halitosis, gingival swelling and tooth loss after TDF use. After excluding the possibility of other drug-related ADRs, TDF was considered a possible cause and switched with tenofovir alafenamide fumarate (TAF). After 6 months, the oral symptoms disappeared, with no additional tooth loss.
What Is New And Conclusion:
This is the first report of such ADRs. The ADR score was 7, indicating tooth loss as a potential TDF-related ADR.
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