Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

372
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
372
Positron Emission Tomography01:29

Positron Emission Tomography

6.7K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modular Europium-Based Nanosensors for the Detection of Sodium and Potassium Ions.

ACS omega·2026
Same author

Development of a Second-Generation RARα Selective Antagonist as an Orally Bioavailable, Effective, Safe, and Reversible Male Contraceptive.

Journal of medicinal chemistry·2026
Same author

Radiation Biology of Radiopharmaceuticals: Beyond External Beam Radiation Therapy.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Synthesis and preliminary evaluation of cardiac imaging with [<sup>68</sup>Ga]Ga-NOTA-CTP in normal and infarcted CD1 mice.

RSC pharmaceutics·2026
Same author

Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic.

Angewandte Chemie (International ed. in English)·2026
Same author

Correction to "From Discovery to Clinical Trial: YCT-529, an Oral NonHormonal Male Contraceptive Targeting the Retinoic Acid Receptor Alpha".

Journal of medicinal chemistry·2026

Related Experiment Video

Updated: Dec 11, 2025

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
11:22

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Published on: August 17, 2016

10.3K

Catechol-Based Functionalizable Ligands for Gallium-68 Positron Emission Tomography Imaging.

M Andrey Joaqui-Joaqui1, Mukesh K Pandey2, Aditya Bansal2

  • 1Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Inorganic Chemistry
|August 22, 2020
PubMed
Summary

New catecholamide (CAM) ligands offer rapid and efficient gallium-68 radiolabeling for positron emission tomography (PET) imaging. TREN-bisGlyGlu-CAM shows particular promise due to its fast kinetics and high stability.

More Related Videos

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

Published on: November 20, 2018

6.8K
Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
10:33

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

876

Related Experiment Videos

Last Updated: Dec 11, 2025

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
11:22

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Published on: August 17, 2016

10.3K
Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

Published on: November 20, 2018

6.8K
Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
10:33

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

876

Area of Science:

  • Radiochemistry
  • Nuclear Medicine
  • Organic Synthesis

Background:

  • Gallium-68 (Ga-68) radiolabeling is crucial for Positron Emission Tomography (PET) imaging.
  • Development of efficient chelators is essential for stable Ga-68 complex formation.

Purpose of the Study:

  • To synthesize and evaluate novel tris-bidentate catecholamide (CAM) ligands for Ga-68 radiolabeling.
  • To assess the suitability of these ligands for PET imaging applications.

Main Methods:

  • Synthesis and characterization of four tris-bidentate catecholamide ligands.
  • Evaluation of radiolabeling efficiency, kinetics, and complex stability with Ga-68.
  • In vivo imaging and ex vivo pharmacokinetic studies.

Main Results:

  • Acyclic CAM ligands demonstrated high radiolabeling yields (>80%) in under 10 minutes at room temperature.
  • Ga-68 complexes exhibited high stability (pGa 21 to >24), comparable or superior to existing ligands.
  • TREN-bisGlyGlu-CAM showed excellent stability in human serum (>95%) and rapid in vivo clearance.

Conclusions:

  • Acyclic CAM ligands provide rapid and mild radiolabeling conditions for Ga-68.
  • TREN-bisGlyGlu-CAM is a highly promising bifunctional chelator for Ga-68 PET imaging.
  • The pendant carboxylic group allows for further conjugation to targeting vectors.