The Impact of Deterministic Signal Loss on OCT Angiography Measurements
Cecilia Czakó1, Lilla István1, Fruzsina Benyó1
1Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
Purpose:
In this study, we aimed at investigating the impact of deterministic signal loss on image quality and, thus, on optical coherence tomography angiography (OCTA) measurements performed by the RTVue-XR Avanti System.
Methods:
Absorptive filters with different optical densities (ODs) were used to simulate signal loss in a controlled way in 30 eyes from 15 healthy subjects. Scan Quality (SQ), provided by the AngioVue software, was applied as a measure of image quality.
Results:
Assessing the effect of decreased light transmittance on SQ values as well as that of attenuated image quality on OCTA parameters revealed a strong systematic dependence between these quantities. Attenuated image quality was associated with significantly decreased macular and peripapillary vessel density (VD) values, and we calculated a correction factor of 2.27% to 3.97% for a one-unit change in SQ for the different VD parameters.
Conclusions:
Our findings suggest that the influence of systematic changes in image quality on OCTA parameters needs to be considered during patient follow-up in order to make valid assessment of progression.
Translational Relevance:
For accurate evaluation of longitudinal changes in OCTA parameters, equal scan quality or using a correction factor is suggested.
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