Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

425
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
425
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

572
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
572
Pleiotropy01:33

Pleiotropy

42.8K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
42.8K
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

338
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
338
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

1.7K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
1.7K
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

628
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
628

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rare case of dedifferentiated liposarcoma of the pectoralis major muscle found on screening mammography.

Radiology case reports·2026
Same author

Apalutamide-Induced Pneumonitis Presenting as Severe Hypoxemic Respiratory Failure in Metastatic Prostate Cancer: A Case Report.

Cureus·2026
Same author

Economic evaluation of the Healthy Early Life Moments in Singapore (HELMS) programme: a study protocol for an integrated lifestyle intervention supported by a mobile health tool for mothers and children in Singapore.

BMJ open·2026
Same author

Strong Families Study: protocol for a co-designed birth cohort study with Aboriginal and Torres Strait Islander families in Queensland, Australia.

BMJ open·2026
Same author

Classification of familial and non-familial ADHD using auto-encoding network and binary hypothesis testing.

Brain research bulletin·2026
Same author

Co-designed principles for establishment of a virtual hospital.

Scientific reports·2026

Related Experiment Video

Updated: Dec 11, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

661

Serrated Polyposis Syndrome: Increasing Awareness and Importance.

Heeyah Song1, Eula Tetangco2, Elizabeth Martin3

  • 1Medicine, Medical College of Georgia, Augusta, USA.

Cureus
|August 22, 2020
PubMed
Summary

Serrated polyposis syndrome (SPS), linked to colorectal cancer (CRC), is increasingly recognized. Diagnosis follows updated WHO criteria for serrated polyps (SPs), with surveillance guidelines evolving.

Keywords:
colorectal cancerserrated polyposis syndromesps

More Related Videos

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
05:58

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

11.3K
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

12.6K

Related Experiment Videos

Last Updated: Dec 11, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

661
Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
05:58

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

11.3K
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

12.6K

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Serrated polyposis syndrome (SPS) is increasingly recognized for its association with colorectal cancer (CRC).
  • Diagnosis relies on updated World Health Organization (WHO) criteria for serrated polyps (SPs).
  • Three subtypes of SPs exist: hyperplastic polyp (HP), sessile serrated lesion (SSL), and traditional serrated adenoma (TSA).

Observation:

  • A 61-year-old male with a history of colon polyps underwent surveillance colonoscopy.
  • Twenty-eight polyps were removed; 21 were SPs, with three exceeding 10 mm.
  • The patient met WHO criteria for SPS, necessitating a one-year follow-up colonoscopy.

Findings:

  • SPS is a significant contributor to colorectal cancer development.
  • The United States Multi-Society Preventive Task Force updated 2020 consensus statements for SP surveillance.
  • Diagnostic criteria for SPS consider cumulative polyp counts over a lifetime.

Implications:

  • Increased recognition of SPS highlights its role in CRC pathogenesis.
  • Updated surveillance guidelines are crucial for managing patients with SPs.
  • Optimal surveillance strategies for SPS require further research and clarification.