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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
Cardiac Troponin Elevation and Outcome in Subarachnoid Hemorrhage
Tehrim Zahid1, Noha Eskander2, Mina Emamy3
1Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Insights
Elevated cardiac troponin I levels after subarachnoid hemorrhage indicate cardiac injury and are linked to poor outcomes. Measuring troponin I in stroke patients aids in predicting severity and improving care.
Area of Science:
- Neurology
- Cardiology
- Critical Care Medicine
Background:
- Aneurysmal subarachnoid hemorrhage frequently leads to cardiopulmonary complications.
- Sympathetic nervous system activation and norepinephrine release contribute to myocardial injury.
- Cardiac troponin I is a key biomarker for diagnosing cardiac damage.
Purpose of the Study:
- To investigate the association between cardiac troponin I elevation and clinical outcomes following subarachnoid hemorrhage.
- To determine the significance of troponin I levels in predicting stroke severity and patient prognosis.
Main Methods:
- Literature search of PubMed using keywords and MeSH terms.
- Inclusion of English-language studies on human subjects within the last 20 years.
- Focus on studies examining cardiac troponin elevation post-subarachnoid hemorrhage.
Main Results:
- Elevated cardiac troponin I levels correlate with worse clinical outcomes.
- Troponin I elevation is significantly associated with stroke severity and neurological status.
- Higher troponin I levels predict longer ICU stays and increased mortality.
Conclusions:
- Cardiac troponin I elevation is a significant predictor of adverse outcomes in subarachnoid hemorrhage patients.
- Measuring cardiac troponin I is recommended for patients presenting with acute stroke.
- Hemodynamic monitoring and supportive care are crucial for improving patient outcomes.
Abstract:
Many cardiopulmonary complications occur after aneurysmal subarachnoid hemorrhage. This is due to sympathetic nervous system activation which results in release of norepinephrine from myocardial sympathetic nerves. Cardiac troponin I is a marker for diagnosis of cardiac injury. Elevated levels of troponin in these patients are associated with worse clinical outcomes. PubMed was searched for literature using regular and Medical Subject Heading (MeSH) keywords for data collection. Papers published in English language involving human subjects within the last 20 years focusing on cardiac troponin elevation following subarachnoid hemorrhage were included. Systemic complications that occur after subarachnoid hemorrhage worsen the clinical outcome of patients and have negative effects on the mortality and morbidity of these patients. Cardiac troponin I elevation is significantly associated with the severity of the stroke, poor neurological status, longer ICU stay, and death. Cardiac troponin I should be measured in patients presented with acute stroke. Hemodynamic monitoring and appropriate supportive care can improve clinical outcomes.
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