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Related Concept Videos

The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Coronary Artery Disease II: Pathophysiology01:26

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Related Experiment Video

Updated: Dec 11, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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Cellular Senescence in Arterial Diseases.

Ippei Shimizu1,2, Tohru Minamino1,3

  • 1Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Journal of Lipid and Atherosclerosis
|August 22, 2020
PubMed
Summary

Cellular senescence, an irreversible cell cycle arrest, contributes to aging and inflammation. Senolysis, the depletion of these senescent cells, shows promise in reversing age-related conditions like arterial diseases without increasing cancer risk.

Keywords:
Arterial diseasesCellular senescenceSenolysis

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Last Updated: Dec 11, 2025

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Area of Science:

  • Gerontology
  • Cell Biology
  • Cardiovascular Research

Background:

  • Cell proliferation is finite, leading to cellular senescence, a state of irreversible cell cycle arrest.
  • Senescent cells exhibit altered morphology, become pro-inflammatory, and accumulate with age, particularly in the cardiovascular system.
  • Accumulated senescent cells are pathogenic, mediating vascular remodeling and chronic inflammation.

Purpose of the Study:

  • To explore the therapeutic potential of eliminating senescent cells.
  • To investigate the impact of senolysis on age-related pathogenic phenotypes.
  • To assess the safety of senolysis regarding tumorigenesis.

Main Methods:

  • Utilized genetic and pharmacological approaches for senescent cell elimination.
  • Conducted studies both in vitro and in vivo.
  • Evaluated the reversal of age-related phenotypes and tumorigenesis risk.

Main Results:

  • Senescent cells can be effectively eliminated using senolysis.
  • Senolysis contributes to the reversal of age-related pathogenic phenotypes.
  • Senolysis does not carry an increased risk of tumorigenesis.

Conclusions:

  • Senolysis is a viable strategy for depleting senescent cells.
  • Senolysis offers a promising therapeutic avenue for age-related disorders, including arterial diseases.
  • This approach opens new research directions in aging and longevity.