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Decreased Threshold of Fasting Serum Glucose for Cardiovascular Events: MASHAD Cohort Study

Fatemeh Sadabadi1, Aida Gholoobi2, Alireza Heidari-Bakavol3

  • 1- Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Reports of Biochemistry & Molecular Biology
|August 22, 2020
PubMed

Insights

Elevated fasting serum glucose (FSG) is linked to cardiovascular disease (CVD) risk in Iran. A new FSG cutoff of 90 mg/dl can help screen for CVD events in this population.

Area of Science:

  • Endocrinology
  • Cardiology
  • Public Health

Background:

  • Cardiovascular disease (CVD) is a leading global cause of death, particularly in Iran.
  • Diabetes mellitus and dyslipidemia are significant risk factors for CVD.
  • Understanding the relationship between glucose levels and CVD is crucial for prevention.

Purpose of the Study:

  • To investigate the association between fasting serum glucose (FSG), lipid profile, and CVD endpoints.
  • To determine an optimal FSG cutoff value for predicting CVD in the MASHAD cohort.
  • To assess the predictive value of FSG for cardiovascular events in an Iranian population.

Main Methods:

  • A 6-year follow-up of MASHAD study participants was conducted.
  • Fasting serum glucose, fasting lipids, and physical examination data were collected.
  • Receiver operating curve (ROC) analysis was used to identify the optimal FSG cutoff point.

Main Results:

  • A MASHAD cutoff of 90 mg/dl for FSG was identified as predictive of CVD outcome.
  • This cutoff demonstrated 54.34% sensitivity and 71.68% specificity (AUC=0.665).
  • Elevated FSG, using the MASHAD cutoff, was associated with a 2.34-fold increase in CVD risk (HR 2.34).

Conclusions:

  • FSG and lipid profiles are significantly related to CVD outcomes in the MASHAD study.
  • Elevated fasting glucose levels strongly correlate with cardiovascular events in the Iranian population.
  • A fasting glucose threshold of 90 mg/dl is proposed for screening cardiovascular events.
Abstract

Keywords:
Cardiovascular disease (CVD)Fasting Serum GlucoseLipid profileMASHAD cohort study

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