[Coinfections in contact lens-associated mycotic keratitis with Pseudomonas or Acanthamoeba]

Area of Science:

• Ophthalmology
• Infectious Diseases

Background:

• Contact lens-associated keratitis is a growing concern.
• Fungal keratitis, though rare, poses significant risks and can be misdiagnosed early.
• Coinfections can complicate treatment-resistant cases.

Purpose of the Study:

• To report on two cases of fungal keratitis with severe coinfections in contact lens wearers.
• To emphasize the diagnostic challenges and treatment strategies for these complex cases.

Main Methods:

• Case report of two patients with initially unclear keratitis.
• Confirmation of fungal keratitis with coinfection by Pseudomonas aeruginosa and Acanthamoeba.
• Treatment involved urgent excimer laser penetrating keratoplasty and 8 weeks of topical therapy.

Main Results:

• Successful treatment outcomes were achieved in both patients.
• Prompt surgical intervention and prolonged topical treatment were key to recovery.

Conclusions:

• Fungal keratitis with coinfections requires serious consideration and prompt, aggressive management.
• Excimer laser penetrating keratoplasty combined with adequate topical treatment offers a successful therapeutic approach.