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Updated: Dec 11, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Interaction of non-coding RNAs and Hippo signaling: Implications for tumorigenesis

Can Liu1, Yangge Wu1, Jian Ma1

  • 1Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; Cancer Research Institute, School of Basic Medical Science, NHC Key Laboratory of Carcinogenesis, Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha, China.

Cancer Letters
|August 22, 2020
PubMed

Insights

The Hippo signaling pathway regulates organ size and is crucial in cancer. Its interaction with non-coding RNAs (ncRNAs) offers potential cancer biomarkers and therapeutic targets.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Genetics

Background:

  • The Hippo signaling pathway is a conserved regulator of organ size, controlling cell proliferation, apoptosis, and stem cell renewal.
  • Aberrant Hippo pathway activity is implicated in the development and metastasis of various cancers.
  • Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, are increasingly recognized for their roles in tumorigenesis.

Purpose of the Study:

  • To review the intricate interactions between the Hippo signaling pathway and ncRNAs.
  • To elucidate the implications of these interactions in cancer development and progression.
  • To explore the potential of these interactions as cancer biomarkers and therapeutic targets.

Main Methods:

  • Literature review of studies investigating Hippo pathway and ncRNA crosstalk.
  • Analysis of research on the functional roles of ncRNAs in Hippo pathway-mediated tumorigenesis.
  • Synthesis of evidence regarding clinical applications of Hippo pathway-ncRNA interactions.

Main Results:

  • The Hippo pathway and ncRNAs exhibit complex regulatory crosstalk influencing cancer.
  • Specific ncRNAs can act as tumor suppressors or oncogenes by modulating Hippo pathway components.
  • These interactions contribute to diverse tumor-promoting or tumor-repressing effects.

Conclusions:

  • The interplay between the Hippo pathway and ncRNAs is a critical factor in tumorigenesis.
  • Understanding these interactions provides novel insights into cancer mechanisms.
  • Hippo pathway-ncRNA networks represent promising avenues for developing cancer biomarkers and therapeutic strategies.
Keywords:
LATS1/2MST1/2YAP1circRNAlncRNAmicroRNA

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