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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Multiple sclerosis in Pakistan: Current status and future perspective.

Zara Shah1, Mohammad Wasay1, Burhan Z Chaudhry2

  • 1Aga Khan University, Karachi, Pakistan.

Journal of the Neurological Sciences
|August 22, 2020
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) is more common in Pakistan than previously thought, with similar features and risk factors to Western countries. More research is needed on disease-modifying therapies (DMTs) and patient registries in Pakistan.

Keywords:
DemyelinatingDisease modifyingMultiple sclerosisPakistanSouth Asia

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Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Multiple sclerosis (MS) is a central nervous system (CNS) demyelinating disease causing disability.
  • Previous perceptions underestimated MS prevalence in Pakistan.
  • Understanding MS epidemiology and treatment in Pakistan is crucial for South Asia.

Purpose of the Study:

  • To review existing literature on Multiple Sclerosis (MS) in Pakistan and South Asia.
  • To present the disease's characteristics and the status of disease-modifying treatments (DMTs).
  • To identify gaps in knowledge and suggest improvements for MS patient care.

Main Methods:

  • Literature review using PubMed, Google Scholar, and Pak Medinet.
  • Analysis of articles focusing on MS in Pakistan and South Asia.
  • Synthesis of data on prevalence, clinical features, risk factors, and treatments.

Main Results:

  • MS prevalence in Pakistan may be around 10 per 100,000 population.
  • Clinical features and risk factors (female preponderance, age of onset, viral infections, smoking, vitamin D deficiency, genetics) mirror Western data.
  • Relapsing-remitting multiple sclerosis (RRMS) is the predominant form; immunomodulatory and immunosuppressive drugs are used.

Conclusions:

  • MS is not rare in Pakistan, exhibiting similar characteristics to those in Western populations.
  • There's a lack of data on the utilization and impact of available disease-modifying therapies (DMTs).
  • Establishing population-based prevalence, a national MS registry, and enhanced patient/doctor education are vital for improving MS care in Pakistan.