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Coagulase-negative staphylococci
R E Neihart1, J S Fried, G R Hodges
1Medical Service, Veterans Administration Medical Center, Kansas City, Mo 64128.
Southern Medical Journal
|April 1, 1988
Summary
Coagulase-negative staphylococci are now significant pathogens, causing various infections linked to medical devices. Treatment involves removing foreign bodies and using targeted antimicrobial agents.
Area of Science:
- Microbiology
- Infectious Diseases
- Medical Technology
Background:
- Coagulase-negative staphylococci (CoNS) were historically viewed as non-pathogenic commensals.
- Advancements in medical technology have led to an increase in CoNS-related infections.
- CoNS are now recognized as significant opportunistic pathogens in healthcare settings.
Purpose of the Study:
- To highlight the evolving role of CoNS as major pathogens.
- To detail the spectrum of infections caused by CoNS.
- To outline current therapeutic strategies for CoNS infections.
Main Methods:
- Literature review of CoNS pathogenesis and clinical significance.
- Analysis of infection types associated with medical devices.
- Summary of treatment modalities for CoNS infections.
Main Results:
- CoNS are implicated in a wide range of infections, including catheter-associated bacteremia, endocarditis, and prosthetic device infections.
- Specific infections include those of joint prostheses, vascular grafts, cardiac pacemakers, cerebrospinal fluid shunts, postoperative wounds, urinary tract, and eyes.
- Therapeutic approaches focus on the removal of infected medical devices and appropriate antimicrobial therapy.
Conclusions:
- Coagulase-negative staphylococci represent a growing threat in clinical settings.
- Prompt identification and management, including device removal and antimicrobial treatment, are crucial.
- Understanding the pathogenicity of CoNS is vital for combating device-associated infections.