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Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach
Yosuke Fukuda1, Kaho Akimoto1, Tetsuya Homma1
1Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, 1-5-8 Shinagawa-ku, Tokyo 142-8555, Japan.
Cellular senescence, particularly involving SIRT1, plays a role in asthma exacerbations. Targeting SIRT1 may offer a new strategy for treating virus-induced asthma attacks.
Area of Science:
- Pulmonology
- Immunology
- Cellular Biology
Background:
- Asthma prevalence is rising globally, with viral infections frequently triggering exacerbations.
- These exacerbations cause significant airway inflammation, reduced quality of life, and increased healthcare utilization.
- Current treatments for virus-induced asthma exacerbations are insufficient.
Purpose of the Study:
- To review the role of Silent Information Regulator 2 homolog sirtuin 1 (SIRT1) in bronchial asthma pathogenesis.
- To examine SIRT1's involvement in inflammatory cells during virus-induced asthma exacerbations.
- To explore SIRT1 as a potential therapeutic target for asthma.
Main Methods:
- Literature review focusing on cellular senescence and SIRT1 in asthma.
- Analysis of studies investigating SIRT1's role in inflammatory pathways.
- Examination of models linking viral infections and SIRT1 levels.
Main Results:
- SIRT1 is implicated in the pathology of both stable and exacerbated asthma.
- Decreased SIRT1 levels are observed in various asthma endotypes and phenotypes.
- SIRT1 is linked to cellular senescence and inflammatory responses in virus-induced exacerbations.
Conclusions:
- SIRT1 is a key factor in the pathogenesis of bronchial asthma.
- Targeting SIRT1 presents a promising novel therapeutic strategy for managing virus-induced asthma exacerbations.
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