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Related Concept Videos

Introduction to Connective Tissues01:11

Introduction to Connective Tissues

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Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Psoriasis and Connective Tissue Diseases.

Toshiyuki Yamamoto1

  • 1Department of Dermatology, Fukushima Medical and Dental University, Hikarigaoka 1, Fukushima 960-1295, Japan.

International Journal of Molecular Sciences
|August 23, 2020
PubMed
Summary

Psoriasis, a chronic inflammatory condition, shares autoimmune disease comorbidities and pathogenesis pathways with connective tissue diseases. However, distinct mechanisms necessitate cautious, individualized treatment approaches.

Keywords:
SLESjögren syndromeStill’s diseasedermatomyositisinnate immunitypsoriatic diseasesarcoidosissystemic sclerosis

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Area of Science:

  • Rheumatology and Immunology
  • Dermatology
  • Systemic Inflammatory Diseases

Background:

  • Psoriasis is increasingly recognized as a systemic inflammatory condition, termed psoriatic disease or syndrome.
  • Autoimmune diseases, including connective tissue diseases, represent significant comorbidities of psoriasis.
  • Shared pathogenetic factors like innate immunity, neutrophil extracellular traps (NETs), type I interferon, and T helper-17 (Th17) pathways are implicated in both psoriasis and connective tissue diseases.

Purpose of the Study:

  • To review the coexistence of psoriasis with various connective tissue diseases.
  • To explore shared and distinct pathogenetic mechanisms between psoriasis and connective tissue diseases.
  • To highlight the importance of cautious therapeutic considerations due to differing disease mechanisms.

Main Methods:

  • Literature review focusing on the intersection of psoriasis and connective tissue diseases.
  • Analysis of shared immunological pathways and genetic backgrounds.
  • Discussion of clinical observations regarding co-occurrence and treatment responses.

Main Results:

  • Evidence suggests shared immunological underpinnings between psoriasis and connective tissue diseases.
  • Significant differences in pathomechanisms and drug responses exist, precluding a one-size-fits-all treatment strategy.
  • The review discusses specific connective tissue diseases in the context of their association with psoriasis.

Conclusions:

  • While psoriasis and connective tissue diseases share common inflammatory pathways, their distinct characteristics necessitate careful clinical evaluation.
  • Therapeutic strategies for one condition may not be directly transferable to the other, emphasizing the need for individualized treatment.
  • Further research into the specific interactions and differences is crucial for optimizing patient care.