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The Hippo Pathway Effector YAP1 Regulates Intestinal Epithelial Cell Differentiation.

Sepideh Fallah1,2, Jean-François Beaulieu1,2

  • 1Laboratory of Intestinal Physiopathology, Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

Cells
|August 23, 2020
PubMed
Summary

YAP1 and TAZ proteins negatively regulate intestinal epithelial cell differentiation. Inhibiting YAP1 increases goblet and absorptive cell differentiation, primarily by affecting the CDX2 transcription factor.

Keywords:
CDX2Hippo pathwayTAZYAP1absorptive cellsdifferentiationgoblet cellintestinal cellstem cell

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