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Pathophysiology of antithrombin III deficiency
1Department of Veterinary Pathology, Texas A & M University College of Veterinary Medicine, College Station.
The Veterinary Clinics of North America. Small Animal Practice
|January 1, 1988
Summary
Acquired antithrombin III deficiency causes a hypercoagulable state, increasing thrombosis risk. Measuring antithrombin III activity aids managing conditions like DIC and nephrotic syndrome.
Area of Science:
- Pathophysiology
- Hematology
- Clinical Medicine
Background:
- Antithrombin III is a key natural inhibitor in hemostasis.
- Acquired deficiency leads to a hypercoagulable state and thrombosis.
- This deficiency is associated with various critical illnesses.
Purpose of the Study:
- To explore the pathophysiology of thrombosis in acquired antithrombin III deficiency.
- To highlight the clinical significance of antithrombin III deficiency.
Main Methods:
- Review of existing literature on antithrombin III deficiency and thrombosis.
- Analysis of the role of antithrombin III in hypercoagulability.
Main Results:
- Acquired antithrombin III deficiency induces a hypercoagulable state.
- Thrombosis is a significant risk in these patients.
- Laboratory determination of antithrombin III activity is crucial.
Conclusions:
- Understanding the pathophysiology is key for managing thrombosis in acquired antithrombin III deficiency.
- Antithrombin III activity measurement is vital for clinical evaluation and treatment.
- This applies to patients with DIC, nephrotic syndrome, and severe hepatopathy.