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Tailor-Made Fluorinated Ionic Liquids for Protein Delivery.

N S M Vieira¹, P J Castro¹, D F Marques¹

¹LAQV, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.

Nanomaterials (Basel, Switzerland)

|August 23, 2020

Summary

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Fluorinated ionic liquids (FILs) show promise for pharmaceutical drug delivery due to their stability and low toxicity. These FILs effectively encapsulate and maintain the biological activity of proteins like lysozyme in novel delivery systems.

Area of Science:

Pharmaceutical Science
Materials Science
Biotechnology

Background:

Pharmaceutical companies face challenges in developing and approving new biological products.
Fluorinated ionic liquids (FILs) possess advantageous properties for pharmaceutical applications, including high surfactant power, stability, and low toxicity.
FILs offer design flexibility through cation-anion combinations for creating effective drug delivery systems.

Purpose of the Study:

To investigate the aggregation behavior of fluorinated ionic liquids (FILs) in protein-compatible media, with and without lysozyme.
To optimize incubation conditions for enhanced protein stability and enzymatic activity within FIL-based delivery systems.
To evaluate the encapsulation efficiency and release kinetics of lysozyme from FIL-based formulations.

Main Methods:

Keywords:

aggregation behavior biological activity delivery systems encapsulation efficiency fluorinated ionic liquids release

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Studied FIL aggregation in aqueous solutions with and without lysozyme.
Optimized protein incubation conditions to ensure enzymatic activity and system stability.
Quantified lysozyme encapsulation efficiency.
Assessed protein release profiles under varying time, temperature, and ultrasound frequency conditions.

Main Results:

FIL aggregation behavior was not significantly affected by the presence of protein or protein buffer.
FIL-based systems demonstrated high encapsulation efficiencies for lysozyme.
The biological activity of lysozyme was maintained during encapsulation and release.
Protein release was successfully modulated by external factors like time, temperature, and ultrasound frequency.

Conclusions:

Fluorinated ionic liquids are suitable for designing stable protein delivery systems.
FILs maintain the structural integrity and biological function of therapeutic proteins.
These findings support the application of FILs for developing advanced pharmaceutical delivery platforms with high encapsulation and controlled release capabilities.