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Published on: January 7, 2019
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Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models
Csilla Ari1,2, Cem Murdun3, Craig Goldhagen3
1Department of Psychology, Behavioral Neuroscience Research Laboratory, University of South Florida, Tampa, FL 33620, USA.
Nutrients
|August 23, 2020
Summary
Exogenous ketone supplements, alternatives to ketogenic diets, improved motor performance in rodent models. These supplements also increased R-beta-hydroxybutyrate levels and managed blood glucose post-exercise.
Area of Science:
- Neuroscience
- Metabolic Science
- Exercise Physiology
Background:
- Nutritional ketosis via ketogenic diets (KD) benefits neurometabolic disorders.
- The impact of exogenous ketone supplements on motor performance remains unclear.
- Exogenous ketones offer an alternative to KD for inducing ketosis.
Purpose of the Study:
- To investigate the effects of various exogenous ketone supplements on motor performance.
- To assess the impact on postexercise blood glucose and R-beta-hydroxybutyrate (R-βHB) levels.
- To compare different ketone formulations (KD, butanediol, ketone-ester, ketone-salt, and combinations) in rodent models.
Main Methods:
- Utilized accelerating rotarod test to evaluate motor performance.
- Measured blood glucose and R-βHB levels postexercise.
- Tested ketone supplements in Sprague-Dawley (SPD) rats, WAG/Rij (WR) rats, and GLUT-1 Deficiency Syndrome (G1D) mice.
Main Results:
- Exogenous ketone supplementation, including KEMCT, KE, KS, and KEKS, enhanced motor performance across different rodent models and administration protocols.
- Supplementation effectively elevated R-βHB levels.
- In some cases, ketone supplements mitigated postexercise blood glucose increases.
Conclusions:
- Exogenous ketone supplements can improve motor performance in rodent models.
- The efficacy of ketone supplementation varies based on rodent strain, ketone formulation, age, and administration frequency.
- Ketone supplements present a viable strategy for managing metabolic dysregulation and improving motor function.
