Design of Liver Functional Reserve Estimation Technique Based on Optical Densitometry

Area of Science:

• Hepatology
• Diagnostic Medicine
• Biomedical Engineering

Background:

• Assessing liver functional reserves is crucial for managing liver disease.
• Current diagnostic methods may have limitations in accurately reflecting hepatodepression.
• Indocyanine green (ICG) plasma elimination is a known indicator of liver function.

Purpose of the Study:

• To develop and validate a modified invasive technique for assessing liver functional reserves.
• To utilize optical densitometry for measuring indocyanine green plasma elimination.
• To evaluate the efficacy of the proposed method in patients with liver disease.

Main Methods:

• A modified invasive approach was developed for liver functional reserve assessment.
• Plasma elimination of indocyanine green was measured using optical densitometry.
• The method was tested on aqueous and albumin solutions, and in patients with liver disease.

Main Results:

• The study successfully measured indocyanine green plasma elimination in various conditions.
• Preliminary data suggests the method's applicability in a clinical setting.
• The technique demonstrated potential for quantifying the degree of hepatodepression.

Conclusions:

• The perfected method offers a novel contribution to diagnostic medicine.
• Accurate diagnosis of liver disease stages and complications can be achieved.
• Rapid correction of patient treatment algorithms can lead to improved outcomes.