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Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications
Simin Nazarnezhad1, Francesco Baino2, Hae-Won Kim3,4,5
1Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
Nanomaterials (Basel, Switzerland)
|August 23, 2020
Summary
Electrospun nanofibers show promise for tissue engineering by promoting blood vessel growth (angiogenesis). Further research is needed to translate these pro-angiogenic scaffolds for regenerating vital organs.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Angiogenesis, the formation of new blood vessels, is crucial for tissue repair and regeneration.
- Biomaterials combined with stem cells or bioactive molecules create pro-angiogenic constructs.
- Electrospun nanofibrous scaffolds are promising for pro-angiogenic strategies.
Purpose of the Study:
- To review recent advancements in designing pro-angiogenic electrospun nanofibers.
- To evaluate the utility of these nanofibers in tissue engineering and regenerative medicine.
- To highlight the potential for regenerating highly vascularized tissues and organs.
Main Methods:
- Incorporation of bioactive components like bioactive glasses (BGs) into polymer nanofibers.
- Loading of biomolecules such as vascular endothelial growth factor (VEGF) for pro-angiogenic activity.
- Seeding of endothelial progenitor cells onto nanofibrous scaffolds to induce angiogenesis.
Main Results:
- Electrospun scaffolds loaded with bioactive components or cells demonstrate pro-angiogenic effects.
- Proven effectiveness in vitro and in vivo for hard (bone) and soft (skin) tissue reconstruction.
- Early-stage translational success, indicating significant future potential.
Conclusions:
- Pro-angiogenic electrospun nanofibers represent a significant development in tissue engineering.
- Further investigation is required to fully realize their potential in regenerating complex, vascularized tissues and organs.
- These scaffolds offer a versatile platform for enhancing vascularization in regenerative medicine applications.
