Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement: function and clinical relevance.

L W Williams1, A W Burks, R W Steele

  • 1Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.

Annals of Allergy
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early-life gut microbiome and egg allergy.

Allergy·2018
Same author

Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions.

Nature communications·2017
Same author

Component-resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness.

Allergy·2016
Same author

Utility of component analyses in subjects undergoing sublingual immunotherapy for peanut allergy.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2015
Same author

Effects of a pre-existing food allergy on the oral introduction of food proteins: findings from a murine model.

Allergy·2014
Same author

Allergen immunotherapy: a new semantic framework from the European Academy of Allergy and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL consensus report.

Allergy·2013
Same journal

Hay fever; a review of the literature for 1945.

Annals of allergy·2010
Same journal

Nasal and sputum smears.

Annals of allergy·2010
Same journal

Determination of penicillin-susceptible strains of bacteria.

Annals of allergy·2010
Same journal

Fleabite reactions; clinical and experimental observations and effect of histamine-azoprotein therapy.

Annals of allergy·2010
Same journal

D.H.E. 45 (dihydroergotamine) in the treatment of allergic megraine.

Annals of allergy·2010
Same journal

Antigenicity of proteins in relation to allergy.

Annals of allergy·2010
See all related articles

The complement system comprises proteins crucial for immunity, with classical and alternative pathways. Deficiencies in complement components can lead to autoimmune or immunodeficiency diseases, including hereditary angioedema.

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • The complement system is a vital part of innate and adaptive immunity.
  • It involves a cascade of proteins that can be activated through classical or alternative pathways.
  • These pathways play critical roles in host defense against pathogens and in clearing cellular debris.

Purpose of the Study:

  • To elucidate the diverse roles of complement system proteins in immune responses.
  • To highlight the significance of complement activation in both acquired and innate immunity.
  • To underscore the clinical implications of complement component deficiencies.

Main Methods:

  • Review of existing literature on complement system pathways.
  • Analysis of the functional roles of various complement proteins.

Related Experiment Videos

  • Correlation of complement system dysfunction with specific diseases.

    • Main Results:

    • The classical pathway, antibody-dependent, is key to acquired immunity against microbes.
    • The alternative pathway provides innate immunity by targeting non-self membranes and amplifies complement activation.
    • Deficiencies in complement components are linked to autoimmune and immunodeficiency disorders.

    Conclusions:

    • The complement system is essential for effective immune surveillance and response.
    • Dysregulation or absence of complement components, such as C1 inhibitor (C1INH), can result in severe clinical conditions like hereditary angioedema.
    • Understanding complement pathways is critical for diagnosing and managing immune-related diseases.