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Rabbit pasteurellosis: induced disease and vaccination
Z S Al-Lebban1, L B Corbeil, E H Coles
1Department of Laboratory Medicine, College of Veterinary Medicine, Kansas State University, Manhattan 66506.
American Journal of Veterinary Research
|March 1, 1988
Summary
Homologous Pasteurella multocida vaccination provided the best protection against pasteurellosis in rabbits. A cross-reactive Escherichia coli J5 mutant offered partial protection, with mucosal routes being more effective than intravenous immunization.
Area of Science:
- Veterinary Microbiology
- Immunology
Background:
- Pasteurellosis, caused by Pasteurella multocida, is a significant concern in animal health.
- Effective vaccination strategies are crucial for controlling Pasteurella multocida infections.
Purpose of the Study:
- To evaluate the efficacy of homologous Pasteurella multocida and cross-reactive Escherichia coli J5 mutant vaccines in rabbits.
- To compare the protective effects of different vaccination routes (intravenous vs. mucosal) against Pasteurella multocida challenge.
Main Methods:
- Rabbits were vaccinated with Pasteurella multocida or a cross-reactive Escherichia coli J5 mutant via intravenous or mucosal routes.
- Vaccinated rabbits were challenged with virulent Pasteurella multocida strains.
- Protection was assessed by survival rates, bacteremia, and antibody titers.
Main Results:
- Homologous Pasteurella multocida vaccination conferred the highest protection against fatal bacteremia.
- The Escherichia coli J5 mutant provided partial protection, demonstrating cross-reactivity.
- Mucosal vaccination routes (aerosol, conjunctival) were more effective than the intravenous route, despite lower serum antibody titers.
Conclusions:
- Heat-stable antigens appear protective against Pasteurella multocida infection.
- The cross-reactive E. coli J5 mutant offers a potential avenue for cross-protective immunization.
- Mucosal immunization routes show promise for enhancing protection against pasteurellosis.