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Retinal toxicity study of intravitreal carboplatin and iproplatin
A Zlioba1, G A Peyman, J Nikoleit
1LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Annals of Ophthalmology
|February 1, 1988
Abstract:
We tested the intravitreal toxicity of two second-generation, antineoplastic, platinum-coordination compounds, carboplatin and iproplatin, in the rabbit. No histologic or electroretinographic changes were observed in doses of 3 micrograms or less. These analogues of cisplatin are 30 times less toxic than the parent compound and may be useful in the prevention of cell proliferation in the vitreous.