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Polymorphisms Involved in Response to Biological Agents Used in Rheumatoid Arthritis

Giovanni Pallio1, Federica Mannino1, Natasha Irrera1

  • 1Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.

Biomolecules
|August 23, 2020
PubMed

Insights

Pharmacogenetics in rheumatoid arthritis (RA) shows varied patient responses to biological drugs. Current data on genetic polymorphisms is inconsistent, limiting personalized treatment recommendations for RA.

Area of Science:

  • Rheumatology
  • Pharmacogenetics
  • Immunology

Background:

  • Rheumatoid arthritis (RA) is a systemic autoimmune disease causing joint destruction.
  • Biological drugs are primary RA therapies, but patient responses vary significantly.
  • Genetic factors are implicated in differential responses to biological treatments.

Purpose of the Study:

  • To review the pharmacogenetics of biological agents used in rheumatoid arthritis treatment.
  • To assess the correlation between genetic polymorphisms and treatment response in RA patients.
  • To evaluate the current evidence for personalized pharmacogenetic approaches in RA therapy.

Main Methods:

  • Systematic review of PubMed literature from 2000-2020.
  • Search terms included "rheumatoid arthritis" and "polymorphisms".
  • Focused on studies investigating genetic polymorphisms and response to biological therapy in RA.

Main Results:

  • Some studies indicate correlations between genetic polymorphisms and RA patient response to biologics.
  • However, findings are frequently lacking in consistency and statistical power.
  • Evidence is insufficient to establish reliable pharmacogenetic markers for guiding RA treatment.

Conclusions:

  • Pharmacogenetics offers a promising avenue for personalized RA treatment.
  • Current pharmacogenetic data for biological therapies in RA is inadequate for clinical decision-making.
  • Further robust research is needed before pharmacogenetic testing can be recommended for RA patients starting biological therapy.
Keywords:
CD20CD80CD86IL-1IL-6TNF-αpolymorphismrheumatoid arthritis

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