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Coffee Intake and Neurocognitive Performance in HIV/HCV Coinfected Patients (ANRS CO13 HEPAVIH)

Saskia Antwerpes1, Camelia Protopopescu1,2, Philippe Morlat3

  • 1Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Économiques & Sociales de la Santé & Traitement de l'Information Médicale, 13385 Marseille, France.

Nutrients
|August 23, 2020
PubMed

Insights

Regular coffee intake may preserve cognitive function in individuals coinfected with HIV and HCV. Elevated coffee consumption showed positive associations with verbal fluency, psychomotor speed, and executive functioning in this population.

Area of Science:

  • Neuroscience
  • Hepatology
  • Infectious Diseases

Background:

  • Coffee is a widely consumed beverage with known neuroprotective properties.
  • HIV-HCV coinfection accelerates aging and causes cognitive impairment, impacting quality of life and treatment adherence.
  • Understanding factors that support cognitive health in this population is crucial.

Purpose of the Study:

  • To investigate the association between regular coffee intake and neurocognitive performance (NCP) in patients coinfected with HIV and HCV.
  • To determine if elevated coffee intake (ECI) is linked to better cognitive outcomes in this specific cohort.

Main Methods:

  • Analysis of data from 139 HIV-HCV coinfected patients from the ANRS CO13 HEPAVIH cohort and HEPAVIH-Psy survey.
  • Linear regression models were employed, adjusting for sociodemographic, clinical, and socio-behavioral factors.
  • Neurocognitive performance was assessed across various domains including verbal fluency, psychomotor speed, and executive functioning.

Main Results:

  • A significant, positive association was found between elevated coffee intake (≥3 cups/day) and enhanced NCP.
  • Specifically, ECI correlated with improvements in verbal fluency, psychomotor speed (coding), and executive functioning.
  • No other factors showed such a consistent positive link to cognitive performance in this cohort.

Conclusions:

  • Elevated coffee intake may play a protective role in maintaining neurocognitive functioning in individuals coinfected with HIV and HCV.
  • Further research could explore the mechanisms behind coffee's neuroprotective effects in this vulnerable population.
  • Findings suggest a potential lifestyle intervention to support cognitive health in HIV-HCV coinfected patients.

Keywords:
HIVcoffeehepatitis Cneurocognitive disorders

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