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Paper-based Devices for Isolation and Characterization of Extracellular Vesicles

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Published on: April 3, 2015

Silane-based modified papers and their extractive phase roles in a microfluidic platform.

Mahin Hashemi Hedeshi¹, Omid Rezvani¹, Habib Bagheri¹

¹Environmental and Bio-Analytical Laboratories, Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516, Tehran, Iran.

Analytica Chimica Acta

|August 23, 2020

Summary

Modified paper-based materials in microfluidic devices offer efficient solid-phase extraction for various analytes. This method enhances extraction performance for detecting antidepressant drugs and toxins with high accuracy in complex samples.

Keywords:

Antidepressant drugs Functionality Gas chromatography–mass spectrometry Microfluidic device Silane–based modified papers

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Microfluidic Devices for Characterizing Pore-scale Event Processes in Porous Media for Oil Recovery Applications

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Published on: January 16, 2018

Area of Science:

Analytical Chemistry
Materials Science
Environmental Science

Background:

Development of novel extractive phases for enhanced analyte recovery.
Need for efficient and stable solid-phase extraction (SPE) methods.
Application of microfluidic systems for improved analytical processes.

Purpose of the Study:

To prepare and evaluate modified paper-based substrates as extractive phases in microfluidic devices.
To investigate the extraction performance for analytes of varying polarities, including antidepressant drugs, organophosphates, and triazine toxins.
To optimize the extraction parameters and assess the method's applicability for real-world sample analysis.

Main Methods:

Modification of paper substrates using different silane reagents (HDTMS, PTES, APTES, EPPTMOS).
Fabrication of microfluidic devices incorporating the modified paper-based extractive phases.
Solid-phase extraction (SPE) coupled with gas chromatography-mass spectrometry (GC-MS) for analyte detection and quantification.
Data analysis using Principal Component Analysis (PCA) and Hierarchical Clustering Analysis (HCA) to understand analyte-sorbent interactions.

Main Results:

Phenyltrimethoxysilane (PTES) modified paper demonstrated optimal performance for quantitative analysis.
Achieved linear ranges for antidepressant drugs (amitriptyline, trimipramine, clomipramine) from 0.02-200 μg L⁻¹.
Obtained low limits of detection (0.005-0.01 μg L⁻¹) for antidepressant drugs using the microfluidic-GC-MS system.
Demonstrated high relative recoveries (95-103%) for tested drugs in urine samples, indicating method reliability.

Conclusions:

Modified paper-based materials integrated into microfluidic devices provide an effective platform for SPE.
The developed method offers high sensitivity and accuracy for the determination of target analytes in complex matrices like urine.
This approach represents a promising advancement in microfluidic-based analytical sample preparation.