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Pathologic features of COVID-19: A concise review
Mohammadreza Tabary1, Shaghayegh Khanmohammadi2, Farnaz Araghi3
1Experimental Medicine Research Center, Tehran University of Medical Center, Tehran, Iran.
Pathology, Research and Practice
|August 23, 2020
Summary
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes COVID-19, affecting multiple organs. Pathological reviews reveal diverse COVID-19-related changes in organs like the lungs and heart, some similar to SARS and MERS.
Area of Science:
- Pathology
- Virology
- Infectious Diseases
Background:
- COVID-19, caused by SARS-CoV-2, emerged in 2019 and became a global pandemic.
- ACE2 receptors, targeted by SARS-CoV-2, are present in various human tissues, suggesting potential multi-organ involvement.
- Early post-mortem studies indicated pathological changes in multiple organs due to COVID-19.
Purpose of the Study:
- To comprehensively review and document COVID-19-related pathological alterations across various organs.
- To elucidate the pathogenesis of COVID-19 by examining histopathological findings.
- To compare COVID-19 pathology with that of SARS and MERS.
Main Methods:
- Systematic review of literature on post-mortem findings in COVID-19 cases.
- Analysis of pathological changes in organs including lungs, heart, liver, kidneys, brain, and others.
- Comparative analysis with pathological data from SARS and MERS infections.
Main Results:
- Diverse pathological changes were identified in multiple organs affected by COVID-19.
- Significant alterations were observed in the lungs, gastrointestinal tract, liver, kidneys, heart, and other systems.
- Many observed pathological changes showed similarities to those seen in SARS and MERS infections.
Conclusions:
- COVID-19 causes widespread pathological alterations affecting numerous organs.
- Pathological examination provides crucial insights into COVID-19 pathogenesis and causes of death.
- Understanding these changes aids in comparing COVID-19 with other coronavirus-related diseases.
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