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High Fibrinogen and Platelets Correlate with Poor Survival in Gastric Cancer Patients

Yi Zhang1, Ni Liu2, Cuixia Liu1

  • 1Department of Gastroenterology, Taizhou People's Hospital, Jiangsu Province, Taizhou, China.

Annals of Clinical and Laboratory Science
|August 23, 2020
PubMed

Insights

High fibrinogen (FIB) and platelet (PLT) levels are linked to poorer outcomes in gastric cancer (GC) patients. These factors may work together to worsen survival rates in individuals with this malignancy.

Area of Science:

  • Oncology
  • Hematology

Background:

  • Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide.
  • Elevated fibrinogen and platelet counts are frequently observed in malignancies and correlate with poor prognosis.

Purpose of the Study:

  • To investigate the association between high fibrinogen and platelet levels and the clinicopathologic features of gastric cancer.
  • To determine the impact of high fibrinogen and platelet levels on the overall survival of gastric cancer patients.

Main Methods:

  • Retrospective analysis of 341 gastric cancer patients.
  • Kaplan-Meier method and chi-squared tests were used to assess correlations between survival and fibrinogen (FIB) and platelet (PLT) levels.

Main Results:

  • Fibrinogen levels correlated with tumor size, lymph node metastasis, and invasion depth (P<0.05).
  • Platelet levels were associated with tumor size (P<0.05).
  • High FIB and PLT levels were significantly linked to reduced overall survival (P<0.05).

Conclusions:

  • High platelet and fibrinogen levels may exert synergistic negative effects on gastric cancer patient outcomes.
  • These findings suggest FIB and PLT levels as potential prognostic biomarkers for gastric cancer.
Abstract

Keywords:
Fibrinogengastric cancermalignancytumor progression

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