Related Experiment Video

Updated: Dec 11, 2025

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.1K

Evaluation of indicators supporting reproducibility and transparency within cardiology literature

J Michael Anderson1, Bryan Wright2, Shelby Rauh2

  • 1Center for Health Sciences, Oklahoma State University, Tulsa, Oklahoma, USA jande31@okstate.edu.

Heart (British Cardiac Society)
|August 23, 2020
PubMed

Insights

Cardiology research lacks transparency, hindering reproducibility. Most studies fail to share data, analysis scripts, or protocols, making it difficult to verify findings and advance scientific understanding.

Area of Science:

  • Cardiovascular Research
  • Medical Informatics
  • Scientific Publishing

Background:

  • Biomedical research reproducibility is a growing concern.
  • The extent of reproducible research in cardiology is not well-defined.

Purpose of the Study:

  • To evaluate the quality of cardiology research by assessing reproducibility and transparency indicators.
  • To identify specific areas for improvement in scientific reporting within cardiology.

Main Methods:

  • Cross-sectional study design analyzing cardiology journal publications from 2014-2019.
  • Searched National Library of Medicine catalogue and full-text PDFs.
  • Assessed 232 publications for eight indicators of reproducibility and transparency using a Google Form.

Main Results:

  • Nearly all publications (96.6%) lacked access to complete, unmodified datasets.
  • A vast majority (98.7%) did not provide analysis scripts.
  • Most studies (98.3%) failed to provide access to complete study protocols.

Conclusions:

  • Current cardiology publications present significant challenges for study outcome reproducibility.
  • There is a critical need for enhanced reproducibility and transparency in cardiology research.
  • Improved sharing of materials, raw data, and methodological details is essential to advance reproducible cardiology research.
Abstract

Keywords:
research approachesstatistics and study design

More Related Videos

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

708
Assessing Cardiac Reprogramming using High Content Imaging Analysis06:02

Assessing Cardiac Reprogramming using High Content Imaging Analysis

Published on: October 26, 2020

1.4K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
653
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
407
Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
1.2K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
307