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Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study

F Sorge1, R De Simone, E Marano

  • 1Department of Neurology, IInd School of Medicine, Naples, Italy.

Cephalalgia : an International Journal of Headache
|March 1, 1988
PubMed

Insights

Flunarizine effectively reduces migraine frequency and duration in children. This study found flunarizine to be a safe and effective prophylactic treatment for childhood migraine.

Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology

Background:

  • Migraine is a common neurological disorder in children.
  • Prophylactic treatments are essential for managing frequent migraine attacks in pediatric populations.

Purpose of the Study:

  • To evaluate the efficacy and safety of flunarizine for migraine prophylaxis in children.
  • To assess the impact of flunarizine on migraine frequency, duration, and side effects.

Main Methods:

  • An 8-month, double-blind, placebo-controlled, crossover trial involving 70 children.
  • Participants received flunarizine (5 mg/day) or placebo for 12 weeks, followed by a 4-week washout and then crossed treatments.

Main Results:

  • Flunarizine significantly reduced headache attack frequency and average duration in both treatment groups.
  • Efficacy was maintained throughout the study period.
  • Common side effects included daytime sedation and weight gain; no serious adverse events were reported.

Conclusions:

  • Flunarizine is an effective prophylactic medication for childhood migraine.
  • The drug demonstrates a favorable safety profile for pediatric use in short-term treatment.

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