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Clinical Course of 195 Critically Ill COVID-19 Patients: A Retrospective Multicenter Study

Shuliang Zhou1, Yadong Yang2, Xingguo Zhang3

  • 1Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Shock (Augusta, Ga.)
|August 23, 2020
PubMed

Insights

Critically ill patients with Coronavirus disease-2019 (COVID-19) often required ventilation and hemodynamic support. High viral load was associated with increased mortality in these severe cases.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Pulmonology

Background:

  • The Coronavirus disease-2019 (COVID-19) pandemic has caused widespread critical illness.
  • The dynamic clinical course and outcomes of critically ill COVID-19 patients require thorough investigation.

Purpose of the Study:

  • To describe the epidemiologic data, clinical features, treatments, and outcomes of critically ill COVID-19 patients.
  • To identify risk factors associated with mortality in severe COVID-19 cases.

Main Methods:

  • Retrospective analysis of 195 critically ill COVID-19 patients in Hubei province, China.
  • Collection and analysis of epidemiologic data, clinical features, treatments, and outcomes.

Main Results:

  • Most critically ill patients were older with higher Acute Physiology and Chronic Health Evaluation II scores.
  • 92.8% received ventilation support, with 49.7% requiring invasive mechanical ventilation (IMV).
  • Notable complications included acute respiratory distress syndrome (ARDS), shock, acute kidney injury, and secondary infections. Overall 28-day mortality was 42.1%.

Conclusions:

  • Acute respiratory distress syndrome (ARDS) and shock were prominent features of critical COVID-19.
  • Ventilation and hemodynamic support are crucial for critical care management.
  • High viral load is linked to mortality in critically ill COVID-19 patients.
Abstract

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