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Epigenetic mechanisms in Tendon Ageing.
Kiran Riasat1, David Bardell1,2, Katarzyna Goljanek-Whysall1
1Department of Musculoskeletal Biology, Institute of Life Course and Medical Sciences, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK.
British Medical Bulletin
|August 23, 2020
Summary
Epigenetic mechanisms influence tendon aging and injury risk. Further research is needed to understand their role in healthy aging and disease predisposition.
Area of Science:
- Molecular Biology
- Gerontology
- Biomaterials Science
Background:
- Tendons are viscoelastic composite materials crucial for force transfer.
- Tendon injuries increase with age, indicating compromised repair and homeostasis.
- Epigenetic mechanisms are implicated in the aging process of tendons.
Purpose of the Study:
- To systematically review the role of epigenetic mechanisms in tendon aging.
- To identify epigenetic factors contributing to age-related tendon pathology.
Main Methods:
- A systematic literature search was conducted across multiple databases.
- The review focused on studies investigating epigenetic mechanisms in aging tendons.
Main Results:
- Epigenetic mechanisms are recognized as important factors in age-related tendon injury.
- The precise role of epigenetics in promoting healthy aging versus pathology remains unclear.
Conclusions:
- Investigating under-researched epigenetic markers, such as genome-wide chromatin accessibility, is crucial.
- Integrating multi-platform datasets via meta-analysis will enhance understanding of the epigenome in aging tendons and disease relevance.
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