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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Host Polymorphisms May Impact SARS-CoV-2 Infectivity.

Patrick Brest1, Sadal Refae2, Baharia Mograbi1

  • 1Université Côte d'Azur, Centre Antoine Lacassagne, CNRS, Inserm, IRCAN, FHU-OncoAge, Nice, F-06189, France.

Trends in Genetics : TIG
|August 24, 2020
PubMed
Summary
This summary is machine-generated.

Germinal polymorphisms may influence susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by affecting viral entry and shedding. This suggests a genetic basis for individual differences in coronavirus disease 2019 (COVID-19) risk.

Keywords:
SNPcoronavirusgenetic variationinfectionpharmacogenetics

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Area of Science:

  • Genetics
  • Virology
  • Immunology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19).
  • Individual susceptibility to infectious diseases can vary significantly.
  • The role of host genetics in viral infection is an area of active research.

Purpose of the Study:

  • To investigate the potential role of germinal polymorphisms in regulating SARS-CoV-2 cellular targets.
  • To explore how genetic variations might influence proteases involved in viral shedding or internalization.
  • To assess the hypothesis of a genetic influence on COVID-19 susceptibility.

Main Methods:

  • Compilation and analysis of a broad public database.
  • Investigating germinal polymorphisms.
  • Examining gene expression related to SARS-CoV-2 targets and proteases.

Main Results:

  • Evidence supports the hypothesis that germinal polymorphisms can regulate SARS-CoV-2 cellular targets.
  • Polymorphisms may also affect proteases controlling viral shedding or internalization.
  • A genetic influence on individual susceptibility to SARS-CoV-2 infection is strongly suspected.

Conclusions:

  • Germinal polymorphisms are implicated in modulating host-pathogen interactions for SARS-CoV-2.
  • Genetic factors may play a significant role in determining an individual's risk for COVID-19.
  • Further research into host genetics can inform personalized risk assessment and therapeutic strategies.