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Contribution of comorbidities to obesity-related asthma in children

J E Lang1

  • 1Duke University School of Medicine, Duke Clinical Research Institute, 301 West Morgan Street, Durham, NC 27701, USA.

Paediatric Respiratory Reviews
|August 24, 2020
PubMed

Insights

Children with obesity face challenges managing asthma due to common related health issues. This review explores how hypovitaminosis D, obstructive sleep apnea, and gastro-esophageal reflux complicate asthma control in obese children.

Area of Science:

  • Pediatric Pulmonology
  • Endocrinology
  • Sleep Medicine

Background:

  • Obesity in children is linked to a higher incidence of difficult-to-control asthma.
  • Obesity-related comorbidities frequently complicate asthma management in pediatric populations.

Purpose of the Study:

  • To review common obesity-related comorbidities that complicate asthma management in children.
  • To highlight the impact of hypovitaminosis D, obstructive sleep apnea, and gastro-esophageal reflux on pediatric asthma control.

Main Methods:

  • Literature review of studies examining obesity, asthma, and related comorbidities in children.
  • Synthesis of current evidence on the interplay between specific comorbidities and asthma severity/control.

Main Results:

  • Hypovitaminosis D, obstructive sleep apnea, and gastro-esophageal reflux are frequently observed comorbidities in children with obesity and asthma.
  • These conditions are associated with poorer asthma control and increased asthma exacerbations.

Conclusions:

  • Effective asthma management in obese children requires addressing co-existing conditions like hypovitaminosis D, obstructive sleep apnea, and gastro-esophageal reflux.
  • Further research is needed to elucidate the precise mechanisms and optimize treatment strategies for these complex cases.

Keywords:
AsthmaEsophageal refluxObesitySleep apneaVitamin D

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