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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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A cell cycle checkpoint for the endoplasmic reticulum.

Maho Niwa1

  • 1Division of Biological Sciences, Section of Molecular Biology, University of California San Diego, NSB#1, Rm 5328, 9500 Gilman Drive, La Jolla, CA 92093-0377, United States of America.

Biochimica Et Biophysica Acta. Molecular Cell Research
|August 24, 2020
PubMed
Summary
This summary is machine-generated.

Cell cycle regulation is vital for health, preventing diseases like cancer. This review explores a newly discovered checkpoint ensuring cells pass on functional endoplasmic reticulum (ER) to daughter cells.

Keywords:
Cell cycleCell cycle checkpointER cell cycle surveillance (ERSU) checkpointER stressEndoplasmic reticulumReticulonSLT2 MAP Kinase

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Cell cycle regulation is crucial for human health, with errors linked to cancer and hereditary diseases.
  • Extensive research has identified cell cycle checkpoints for DNA replication and segregation.
  • However, checkpoints for cytoplasmic component division, like organelles, are less understood.

Purpose of the Study:

  • To review recent findings on cell cycle checkpoints for organelle division.
  • To highlight the discovery of an endoplasmic reticulum (ER) division checkpoint in Saccharomyces cerevisiae.
  • To emphasize the importance of such checkpoints for cellular inheritance.

Main Methods:

  • Review of existing literature on cell cycle regulation and organelle inheritance.
  • Focus on studies utilizing the model organism Saccharomyces cerevisiae.
  • Analysis of research identifying specific checkpoint mechanisms for ER division.

Main Results:

  • Recent work in Saccharomyces cerevisiae has uncovered a checkpoint governing ER inheritance.
  • This checkpoint ensures the functional endoplasmic reticulum is passed to the daughter cell.
  • The findings suggest conserved mechanisms for organelle division checkpoints.

Conclusions:

  • Checkpoint mechanisms for cytoplasmic components, particularly the ER, are essential for cell viability.
  • The discovery in Saccharomyces cerevisiae provides a model for understanding ER inheritance.
  • Further research is needed to explore similar checkpoints in other organisms and organelles.