Related Experiment Videos
Sequence-specific chemical modification of a hybrid bacteriophage M13 single-stranded DNA by alkylating
V V Vlassov1, V F Zarytova, I V Kutyavin
1Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
FEBS Letters
|April 25, 1988
Abstract:
Alkylating oligonucleotide derivatives react with the complementary sequences in hybrid M13mp7 bacteriophage single-stranded DNA and destroy the infecting ability of the DNA. The reagents do not damage M13mp9 single-stranded DNA lacking the target nucleotide sequence.