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Dynamic expression of MMP28 during cranial morphogenesis

Nadege Gouignard1,2, Eric Theveneau1, Jean-Pierre Saint-Jeannet2

  • 1Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|August 25, 2020
PubMed

Insights

Matrix metalloproteinase-28 (MMP28) is expressed in Xenopus embryos during development. This secreted protein is found in cranial placodes near neural crest cells, suggesting a role in their interaction.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Matrix metalloproteinases (MMPs) are crucial for extracellular matrix remodeling.
  • MMP28, a recently identified MMP, plays roles in wound healing, immunity, and cell survival.
  • MMP28 is expressed during human and mouse embryogenesis.

Purpose of the Study:

  • To detail the expression pattern of MMP28 in Xenopus laevis embryos.
  • To investigate the potential role of MMP28 in embryonic development, particularly in neural crest and placode interactions.

Main Methods:

  • Analysis of MMP28 expression during Xenopus laevis embryonic development.
  • Localization studies to identify specific tissues and developmental stages of MMP28 expression.

Main Results:

  • MMP28 exhibits maternal expression in Xenopus embryos.
  • Expression accumulates at neurula and tail bud stages.
  • MMP28 is specifically localized in cranial placode territories adjacent to migrating neural crest cells.

Conclusions:

  • MMP28 is maternally provided and dynamically expressed during Xenopus embryogenesis.
  • The localization of MMP28 suggests a role in mediating interactions between neural crest cells and cranial placodes.
  • Further research is warranted to elucidate MMP28's function in neural crest development and morphogenesis.
Keywords:
MMPXenopuscranial placodesembryogenesisneural crest

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