Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

12.4K
Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
12.4K
Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

19.3K
Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
19.3K
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

28.2K
The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight...
28.2K
Tight Junctions01:29

Tight Junctions

6.5K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
6.5K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.0K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.0K
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

12.1K
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
12.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nuclear position controls the activity of cortical actomyosin networks powering simultaneous morphogenetic events.

Nature communications·2025
Same author

A mechanical wave travels along a genetic guide to drive the formation of an epithelial furrow during Drosophila gastrulation.

Developmental cell·2024
Same author

Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation.

Nature communications·2022
Same author

Composite morphogenesis during embryo development.

Seminars in cell & developmental biology·2021
Same author

A two-tier junctional mechanism drives simultaneous tissue folding and extension.

Developmental cell·2021
Same author

Cellular and Supracellular Planar Polarity: A Multiscale Cue to Elongate the <i>Drosophila</i> Egg Chamber.

Frontiers in cell and developmental biology·2021

Related Experiment Video

Updated: Dec 11, 2025

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

12.0K

Cell intercalation in a simple epithelium.

Matteo Rauzi1

  • 1Université Côte d'Azur, CNRS, Inserm, iBV, Nice, France.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|August 25, 2020
PubMed
Summary

Cell intercalation drives tissue development and disease. In simple epithelia, cells exchange neighbors medio-laterally, maintaining tissue integrity through combined apical and basal mechanisms.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Tissue Engineering

Background:

  • Cell intercalation is a fundamental process in tissue morphogenesis, homeostasis, and diseases like cancer.
  • Understanding the mechanisms controlling cell intercalation is crucial for tissue development and repair.
  • Simple epithelial tissues exhibit unique intercalation behaviors, maintaining structural integrity.

Purpose of the Study:

  • To elucidate the fundamental mechanisms controlling medio-lateral cell intercalation in simple epithelial tissues.
  • To explore how cells maintain apical-basal architecture and epithelial integrity during topological changes.
  • To investigate the combinatory set of mechanisms utilized by cells for topological transformation.

Main Methods:

  • Observational studies of cell behavior in simple epithelial tissues.
Keywords:
E-cadherin adhesionactomyosin flowactomyosin tensionjunction remodelling

More Related Videos

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

2.0K
Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

72.0K

Related Experiment Videos

Last Updated: Dec 11, 2025

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

12.0K
Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

2.0K
Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

72.0K
  • Analysis of cell-cell interactions and neighbor exchange dynamics.
  • Investigation of apical and basal cellular mechanisms during intercalation.

    • Main Results:

    • Medio-lateral cell intercalation in simple epithelia involves cells exchanging neighbors while preserving apical-basal architecture.
    • Epithelial integrity is maintained throughout the intercalation process.
    • A combination of apical and basal cellular mechanisms facilitates topological transformation.

    Conclusions:

    • Medio-lateral cell intercalation in simple epithelia is a robust and plastic process.
    • The coordinated action of apical and basal mechanisms is essential for successful cell intercalation.
    • This process serves as a model for understanding tissue morphogenesis and related diseases.