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Published on: July 19, 2018
Multi-sites polycyclodextrin adsorbents for removal of protein-bound uremic toxins combining with hemodialysis
Jingyu Li1, Lulu Han1, Jian Xie1
1Liaoning Key Laboratory of Molecular Recognition and Imaging, School of Bioengineering, Dalian University of Technology, Dalian 116023, PR China.
Abstract:
Accumulation of protein-bound uremic toxins (PBUTs) has a high incidence in the blood of hemodialysis-treated patients with chronic kidney disease. Development of adsorbent for the high-efficient, selective, and removal of various PBUTs is still challenging because of their strong interactions to the corresponding binding proteins and the complex blood background. Herein, we reported poly-cyclodextrins adsorbents with multi adsorption-sites for PBUTs removal from plasma. Compared to poly-α-cyclodextrin and poly-γ-cyclodextrin, poly-β-cyclodextrin (PβCD) showed the best adsorption capability and the maximum p-cresol sulfate (PCS, a model PBUT) binding capacity of PβCD (263 mg g-1). Combining with hemodialysis, PβCD adsorbents added into the dialysate can remove 96 % PCS in the plasma via adsorbent once-through mode. Additionally, various PBUTs co-exsiting in the plasma could be effectively removed, exhibiting high-concentrition PBUT adsorption property of PβCD. We expect that the PCD adsorbents combining with hemodialysis therapy may become a promising potential for clinical PBUT removal.
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