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Does non-invasive ventilation change metabolic markers in children with obstructive sleep apnoea? A systematic review
Christopher Gerdung1,2, Sara Rodriguez-Lopez1,2, Stefan Palkowski1,2
1Pediatrics, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, Canada.
Insights
This systematic review examines non-invasive ventilation (NIV) effects on metabolic markers in children with obstructive sleep apnoea (OSA). It synthesizes evidence to guide clinical approaches for pediatric OSA and associated metabolic conditions.
Area of Science:
- Pediatric Endocrinology
- Sleep Medicine
- Cardiovascular Health
Background:
- Obstructive sleep apnoea (OSA) is prevalent in children and linked to metabolic issues like obesity and cardiovascular disease.
- Childhood OSA is associated with metabolic syndrome markers, including hypertension, glucose intolerance, and dyslipidemia.
- Emerging research explores non-invasive ventilation (NIV) for improving metabolic markers in pediatric OSA.
Purpose of the Study:
- To systematically review and synthesize evidence on the impact of NIV on metabolic markers in children diagnosed with OSA.
- To provide a comprehensive overview of current research regarding NIV's therapeutic potential in pediatric metabolic health.
- To inform clinical practice concerning the management of childhood OSA and its metabolic sequelae.
Main Methods:
- Systematic search of electronic databases and grey literature for relevant pediatric interventional studies.
- Inclusion of randomized controlled trials and cohort studies, with or without comparison groups.
- Independent dual-reviewer screening of titles/abstracts and full texts, followed by data extraction and potential meta-analysis.
Main Results:
- This section is to be populated upon completion of the systematic review and data analysis.
- The review will report aggregate data and perform meta-analysis where feasible.
- Findings will detail the effects of NIV on specific metabolic markers in pediatric OSA patients.
Conclusions:
- This systematic review will provide crucial insights for clinicians managing children with OSA and metabolic syndrome.
- The findings have the potential to influence treatment strategies for pediatric OSA and obesity.
- Dissemination of results will occur through abstract and manuscript publications.
Introduction:
Obstructive sleep apnoea (OSA) is not only common within paediatrics but is associated with critical childhood metabolic morbidity such as obesity, cardiovascular disease and glucose tolerance impairment. Increasing evidence suggests an association between childhood OSA and metabolic syndrome such as markers of cardiovascular disease, systemic hypertension, glucose intoleranceand increased lipid profile. Recent studies have targeted changes in metabolic markers in children using non-invasive ventilation (NIV) but no systematic reviews are available to summarise this emerging evidence. The purpose of this systematic review is to provide systematic synthesis of the evidence on the effect of NIV use on metabolic markers in children with OSA.
Methods And Analysis:
A systematic search of electronic databases and grey literature will include paediatric interventional studies (random controlled trials, cohort studies) with and without a comparison group. Two reviewers will independently undertake the two step process of title/abstract and full-text screening. Data will be extracted and assessed, with aggregate data being reported. When the data allow, meta-analysis will be performed.
Ethics And Dissemination:
There are no ethical concerns with this systematic review, as data have previously been published. This review will inform clinicians taking care of children with OSA and obesity/metabolic syndrome about the potential effects of NIV therapies on metabolic markers and has the potential to change the approach to childhood OSA and obesity. Results of this systematic review will be submitted for dissemination in abstract and manuscript form.
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