Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibiotic-associated hypoprothrombinaemia.

J J Lipsky1

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

The Journal of Antimicrobial Chemotherapy
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide.

Gut·2001
Same author

Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease.

Gut·2001
Same author

Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood.

Journal of chromatography. B, Biomedical sciences and applications·2001
Same author

Overview--in vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites.

Chemico-biological interactions·2001
Same author

In vivo inhibition of aldehyde dehydrogenase by disulfiram.

Chemico-biological interactions·2001
Same author

Determination of in vivo adducts of disulfiram with mitochondrial aldehyde dehydrogenase.

Biochemical pharmacology·2001

Antimicrobial drugs can cause hypoprothrombinemia, a serious adverse effect. This review suggests that certain antibiotics, not gut bacteria depletion, may inhibit vitamin K-dependent clotting factor synthesis via thiol groups.

Area of Science:

  • Pharmacology
  • Hematology
  • Microbiology

Background:

  • Hypoprothrombinemia is a serious adverse effect linked to antimicrobial therapy.
  • This condition is often attributed to the disruption of vitamin K-producing intestinal bacteria by antibiotics.

Purpose of the Study:

  • To review evidence supporting or refuting the hypothesis that antibiotic-induced gut bacteria depletion causes hypoprothrombinemia.
  • To investigate the mechanism of antibiotic-associated hypoprothrombinemia in humans and experimental animals.

Main Methods:

  • Literature review of studies in experimental animals and humans.
  • Analysis of reported cases of antibiotic-associated hypoprothrombinemia.
  • Assessment of the proposed mechanisms of hypoprothrombinemia.

Related Experiment Videos

Main Results:

  • The hypothesis linking hypoprothrombinemia solely to the destruction of intestinal bacteria is questioned.
  • Evidence suggests certain antibiotics with thiol-leaving groups may directly inhibit vitamin K-dependent clotting factor synthesis.
  • The mechanism involves the thiol group interfering with a critical step in coagulation factor production.

Conclusions:

  • The depletion of intestinal bacteria may not be the primary cause of antibiotic-associated hypoprothrombinemia.
  • Antibiotics containing thiol-leaving groups present a plausible alternative mechanism for causing hypoprothrombinemia.
  • Further research into the direct inhibitory effects of specific antibiotics on coagulation pathways is warranted.