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Updated: Dec 11, 2025
Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
Total Synthesis of Glycosylated Human Interferon-γ
Xiaoyi Wang1, Anneliese S Ashhurst1,2,3, Luke J Dowman1
1School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Abstract:
Interferon-γ (IFN-γ) is a glycoprotein that is responsible for orchestrating numerous critical immune induction and modulation processes and is used clinically for the treatment of a number of diseases. Herein, we describe the total chemical synthesis of homogeneously glycosylated variants of human IFN-γ using a tandem diselenide-selenoester ligation-deselenization strategy in the C- to N-terminal direction. The synthetic glycoproteins were successfully folded, and the structures and antiviral functions were assessed.
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