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Sex differences in circulating proteins in heart failure with preserved ejection fraction
Susan Stienen1, João Pedro Ferreira2,3, Masatake Kobayashi2
1Université de Lorraine, INSERM, Centre d'Investigation Clinique et Plurithématique 1433, INSERM U1116, CHRU de Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France. s.stienen@amc.uva.nl.
Biology of Sex Differences
|August 25, 2020
Summary
Sex differences in circulating proteins were identified in heart failure with preserved ejection fraction (HFpEF) patients. Nine proteins showed differential expression, offering insights into HFpEF pathophysiology.
Area of Science:
- Cardiology
- Proteomics
- Sex Differences in Disease
Background:
- Heart failure with preserved ejection fraction (HFpEF) disproportionately affects women.
- Understanding sex-based pathophysiological mechanisms in HFpEF is crucial.
- Limited research exists on sex differences in circulating proteins within HFpEF cohorts.
Purpose of the Study:
- To investigate sex differences in circulating protein profiles among patients with HFpEF.
- To identify specific proteins differentially expressed between female and male HFpEF patients.
- To explore potential links between these proteins and HFpEF pathophysiology.
Main Methods:
- Analysis of 415 circulating proteins in 392 HFpEF patients from the MEDIA-DHF study.
- Assessment of sex differences using adjusted logistic regression.
- Evaluation of protein associations with cardiovascular outcomes via Cox regression, including sex interaction.
Main Results:
- Nine proteins exhibited differential expression between female and male HFpEF patients.
- Women showed higher levels of LPL, PLIN1 (lipid metabolism), LHB, IGFBP3, IL1RL2 (transcriptional regulation), and Ep-CAM (hemostasis).
- Men showed higher levels of MMP-3 (extracellular matrix), NRP1 (developmental processes), and ACE2 (metabolism).
Conclusions:
- This study identified 9 differentially expressed circulating proteins between sexes in chronic HFpEF.
- These protein differences may elucidate underlying pathophysiological mechanisms contributing to HFpEF.
- Further research is warranted to explore the functional roles of these proteins in HFpEF.
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