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Domperidone prescribing patterns in pediatric patients before and after safety warning in South Korea

Kiyon Rhew, Nayoung Han, Amie J Goodin

    International Journal of Clinical Pharmacology and Therapeutics
    |August 25, 2020
    PubMed

    Insights

    Korean pediatric domperidone prescriptions decreased significantly after a 2014 safety warning on cardiac risks. Prescribing patterns improved, reducing dosage, duration, and interacting drug co-prescriptions, enhancing child safety.

    Area of Science:

    • Pediatric Pharmacology
    • Drug Safety and Pharmacovigilance
    • Public Health Policy

    Background:

    • A 2014 safety warning was issued by the Korean Ministry of Food and Drug Safety (MFDS) regarding potential adverse cardiac effects of domperidone in children.
    • Domperidone is a medication commonly prescribed for gastrointestinal issues in pediatric populations.

    Purpose of the Study:

    • To evaluate the impact of the 2014 MFDS safety warning on domperidone prescribing trends in pediatric patients.
    • To compare domperidone prescription patterns before and after the safety warning.

    Main Methods:

    • Analysis of national health insurance data for patients under 18 years old in 2011 and 2016.
    • Assessment of prescribing patterns including dosage, duration, and co-prescribed medications.

    Main Results:

    • Domperidone prescriptions in pediatrics decreased by 30% from 2011 to 2016.
    • Significant reductions were observed in prescriptions with high daily dosages (>30 mg) and long continuous use (>7 days).
    • Co-prescriptions of interacting medications with domperidone also significantly decreased.

    Conclusions:

    • The 2014 MFDS safety warning led to improved pediatric domperidone prescribing practices.
    • Enhanced drug safety for children was achieved through reduced prescription frequency, shorter treatment durations, and fewer interacting drug co-prescriptions.
    Abstract

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