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Effect of platelet count on long-term prognosis of cerebral infarction
Fei Ye1, Guan-Shui Bao2, Heng-Shi Xu3
1Department of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Insights
Patients with moderate platelet counts (126-225×109/L) showed better recovery after cerebral infarction (CI). Continuous aspirin use significantly improved neurological function recovery in CI patients during rehabilitation.
Area of Science:
- Neurology
- Hematology
- Rehabilitation Medicine
Background:
- Cerebral infarction (CI) poses significant long-term disability challenges.
- Understanding factors influencing post-CI recovery is crucial for effective secondary prevention strategies.
- Platelet (PLT) count is a potential biomarker for predicting outcomes in CI patients.
Purpose of the Study:
- To investigate the correlation between platelet (PLT) count and functional outcomes, measured by the modified Rankin scale (mRS), in cerebral infarction (CI) patients during later-stage rehabilitation.
- To assess the impact of PLT count on neurological function recovery and long-term prognosis after CI.
- To evaluate the role of aspirin in conjunction with PLT count in CI patient rehabilitation.
Main Methods:
- A cohort of 180 cerebral infarction (CI) patients were stratified into three groups based on platelet (PLT) count: low (<125×109/L), medium (126-225×109/L), and high (>226×109/L).
- The modified Rankin scale (mRS) was assessed at three months and one year post-onset to evaluate functional outcomes and long-term prognosis.
- Statistical analyses, including ANOVA and repeated measures ANOVA, were employed to determine significant differences and effects.
Main Results:
- Ninety-nine patients completed the study with complete data.
- A statistically significant difference in mRS was observed at three months (F=6.714, P=0.002) and one year (F=6.860, P=0.002).
- Patients in the medium PLT group exhibited the lowest mRS scores at both time points, indicating better neurological function recovery.
- Continuous rehabilitation significantly improved outcomes from three months to one year (F=35.528, P<0.001), particularly for patients consistently taking aspirin (F=50.908, P<0.001).
Conclusions:
- A moderate platelet count (126-225×109/L) is associated with better functional recovery and neurological improvement in cerebral infarction (CI) patients.
- Continuous aspirin therapy significantly enhances rehabilitation outcomes in CI patients over a 9-month period.
- Aspirin serves a dual role in CI management as both a secondary preventive agent and a facilitator of post-stroke rehabilitation.
Objective:
This study aimed to analyze the correlation between platelet (PLT) count and the modified Rankin scale (mRS) in patients with cerebral infarction (CI) at the later stage of rehabilitation, which can be used to guide the secondary prevention strategy of CI.
Methods:
A total of 180 CI patients were divided into three groups according to PLT count: low PLT group (<125×109/L), medium PLT group (126- 225×109/L) and high PLT group (>226×109/L). The mRS was evaluated after three months and one year, respectively, and the difference in long-term prognosis between groups was analyzed. The mRS is an ordered scale coded from 0 (no symptoms at all) through 5 (severe disability) 6 (death).
Results:
Finally, a total of 99 patients had complete data. The results of the multiple comparisons among the three groups were as follows: the analysis of variance of the mRS at three months after onset yielded F = 6.714 and P = 0.002, and the difference was statistically significant. The mRS was lowest in the medium PLT group (2.09±1.465), and neurological function recovery was the best. After one year, the mRS for the medium PLT group was the lowest (1.49±1.523), with F = 6.860 and P = 0.002. The repeated measures analysis of variance revealed that the effect of continuous rehabilitation was significant in the interval from three months to one year after onset (F = 35.528, P < 0.001). This was very significant, especially for patients taking aspirin (F = 50.908, P < 0.001). However, for patients who did not take aspirin, the effect of continuous rehabilitation was not obvious during the nine months, and the difference between the results of two mRS measurements was not statistically significant (F = 1.089, P = 0.308).
Conclusions:
Patients with a PLT count of 126- 225×109/L had the lowest mRS between three months and one year after onset, but had the best recovery of nerve function. Patients who persisted in taking aspirin continued to significantly recover during the 9-month period, from three months to one year after onset. Aspirin is not only a secondary preventive drug, but also an important drug to promote the rehabilitation of CI patients.
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