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Updated: Dec 11, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Crusted Scabies Complicated with Herpes Simplex and Sepsis
Arghavan Azizpour1, Maryam Nasimi1, Alireza Ghanadan2,3
1Department of Dermatology, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Crusted scabies, a contagious skin infestation, can rarely lead to Kaposi's varicelliform eruption (KVE), a severe herpes simplex virus infection. This case highlights the importance of recognizing and treating this rare complication to prevent sepsis.
Area of Science:
- Dermatology
- Infectious Diseases
- Virology
Background:
- Crusted scabies is a severe, contagious skin infestation caused by *Sarcoptes scabiei*.
- Kaposi's varicelliform eruption (KVE) is a widespread herpes simplex virus infection often seen in patients with underlying skin conditions.
- The co-occurrence of crusted scabies and KVE is exceptionally rare.
Observation:
- A middle-aged woman presented with crusted scabies.
- She subsequently developed Kaposi's varicelliform eruption superimposed on her crusted scabies.
- The patient's condition was complicated by sepsis.
Findings:
- This case represents a rare instance of Kaposi's varicelliform eruption occurring in the context of crusted scabies.
- The patient received treatment with intravenous meropenem, vancomycin, and acyclovir.
- She recovered and was discharged in good condition within two weeks.
Implications:
- Early recognition and prompt management of KVE in crusted scabies patients are crucial.
- This rare complication can lead to severe outcomes like sepsis if not treated effectively.
- Further case reports may elucidate the pathogenic mechanisms and optimal treatment strategies for this rare condition.
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