Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subacute acetaminophen overdose after incremental dosing.

R D Mathis1, J S Walker, D W Kuhns

  • 1Department of Emergency Medicine, Darnall Army Community Hospital, Fort Hood, Texas.

The Journal of Emergency Medicine
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modelling the effect of first-wave COVID-19 on mental health services.

Operations research for health care·2022
Same author

High time resolution measurements of droplet evaporation kinetics and particle crystallisation.

Physical chemistry chemical physics : PCCP·2021
Same author

Inactivation of Milkborne Foot-and-Mouth Disease Virus at Ultra-High Temperatures <sup>1</sup>.

Journal of food protection·2019
Same author

Persistence of Foot-and-Mouth Disease Virus in Dried Casein <sup>1</sup>.

Journal of food protection·2019
Same author

Step by step: reconstruction of terrestrial animal movement paths by dead-reckoning.

Movement ecology·2015
Same author

A new approach to determine vapour pressures and hygroscopicities of aqueous aerosols containing semi-volatile organic compounds.

Physical chemistry chemical physics : PCCP·2014
Same journal

Drip-and-Ship versus Mothership Model in Acute Ischemic Stroke: A Meta-Analysis Stratified by Stroke System Integration.

The Journal of emergency medicine·2026
Same journal

Response to: "Letter to the Editor Regarding Cervical Spine Clearance in Adult and Pediatric Trauma: A Systematic Review".

The Journal of emergency medicine·2026
Same journal

Ultrasound Characterization of the Distal Thigh Great Saphenous Vein Dimensions in Children and Adults: Implications for Peripheral Rescue Access.

The Journal of emergency medicine·2026
Same journal

A Shadow in the Right Ventricle.

The Journal of emergency medicine·2026
Same journal

Structural Determinants of Telehealth Use Among Patients Presenting to an Urban Safety-Net Emergency Department.

The Journal of emergency medicine·2026
Same journal

Comparison of Over-the-Head and Standard Lateral Cardiopulmonary Resuscitation: A Prospective Crossover Simulation Study.

The Journal of emergency medicine·2026
See all related articles

This case report details acetaminophen poisoning from a 25-hour overdose. N-acetylcysteine therapy proved effective for this subacute overdose, highlighting treatment challenges.

Area of Science:

  • Toxicology
  • Pharmacology
  • Internal Medicine

Background:

  • Acetaminophen (APAP) overdose is a common cause of acute liver injury.
  • Assessing hepatotoxic risk in incremental or subacute overdoses presents unique challenges compared to single-event ingestions.

Observation:

  • A patient presented with hematemesis seven hours after ingesting 26g of acetaminophen over 25 hours.
  • Initial laboratory findings included an acetaminophen level of 150 µg/mL and normal SGOT.
  • The patient received N-acetylcysteine (NAC) therapy.

Findings:

  • The patient recovered without complications, demonstrating the efficacy of NAC in subacute overdose scenarios.
  • The case underscores the difficulty in predicting acetaminophen's hepatotoxic potential with incremental dosing.

Related Experiment Videos

Implications:

  • This case highlights the importance of considering N-acetylcysteine treatment even in delayed or incremental acetaminophen exposures.
  • It emphasizes the need for careful clinical judgment when managing complex acetaminophen poisoning cases.
  • Further research into risk stratification for subacute acetaminophen overdoses may be warranted.